Licensing the inflammasome

Distinct Licensing of IL-18 and IL-1β Secretion in Response to NLRP3 Inflammasome Activation

Inflammasome activation permits processing of interleukins (IL)-1β and 18 and elicits cell death (pyroptosis). Whether these responses are independently licensed or are "hard-wired" consequences of caspase-1 (casp1) activity has not been clear. Here, we show that that each of these responses is independently regulated following activation of NLRP3 inflammasomes by a "non-canonical" stimulus, th...

The inflammasome

What is it? The inflammasome is a multiprotein complex of more than 700 kDa that is responsible for the activation of caspases 1 and 5, leading to the processing and secretion of the pro-inflammatory cytokines IL-1β and IL-18. Two types of inflammasome have been identified to date — the NALP1 inflammasome, composed of NALP1, the adaptor protein ASC, caspase 1 and caspase 5, and the NALP2/3 infl...

• Licensing

oo many organizations view electronic records management (ERM) software selection through a narrow lens. Some enterprises will create massive spreadsheet-based matrices with lists of features and functions broken down in minute detail. These features and functions are weighted by priority, then added and scored to rank vendors and products based on empirical data. This can be a useful exercise ...

Identification of the Inflammasome

Licensing by Modification 217 Licensing by Modification 1. Modification and Direction of Licensing 1. Modification and Direction of Licensing 1. Modification and Direction of Licensing 1. Modification and Direction of Licensing 1. Modification and Direction of Licensing

This paper looks at the phenomena of licensing by modification, whereby an unacceptable noun phrase is redeemed by the presence of a modifier or an unavailable reading for a noun phrase is made available with the addition of a modifier. It argues that an optimal account of such phenomena should derive these effects from the interaction of the meanings of individual expressions in the sentence r...